Misleading In DNA Building Blocks Boosts Colon Cancer: Recent Study

Overview

• Post By : Kumar Jeetendra


• Source: University of Umea


• Date: 13 Apr,2016

Researcher from University of Umea detected a relation in between DNA building blocks and colon cancer, which suggests during cell division 4 DNA building blocks are required for proper copying of DNA without appearance of harmful mutations in traits.

Team of researcher detected type of protein named SAMHD1 which play a key role in breaking down of DNA building blocks (dNTPS) and is often mutated in colon cancer cells, while experiment in yeast and mice and at results researcher finds this cancer specific fuction removes this protein SAMHD1 which causes an imbalance in DNA building blocks.

According to researcher,

"Together with other researchers, we have previously shown that small changes in the levels of DNA building blocks increase the mutation rates in yeast cells," says Professor Andrei Chabes, one of the researchers at Umeå University behind the new findings. "This is what got us interested in studying the proteins involved in the regulation of dNTPS in cancerous cells. Our objective was to identify mutations that affect dNTPS levels and thus increase the mutation rate in cancer cells."

This concern research recently appears in Proceedings of the National Academy of Sciences.

Note: the above story is for information purposes for more information go through original story source.

Story source: University of Umea

Journal References

Matilda Rentoft, Kristoffer Lindell, Phong Tran, Anna Lena Chabes, Robert J. Buckland, Danielle L. Watt, Lisette Marjavaara, Anna Karin Nilsson, Beatrice Melin, Johan Trygg, Erik Johansson, Andrei Chabes. Heterozygous colon cancer-associated mutations ofSAMHD1have functional significance. Proceedings of the National Academy of Sciences, 2016; 201519128 DOI: 10.1073/pnas.1519128113