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Researcher from BIOSS – Centre for Biological Signalling Studies recently done an amazing research and developed a type of microfluidic chip for better analysis of adipose tissue which is primary energy store in humans
Research uses microfluidic chip to know how adult stem cells converted into fat cells in adipose tissue. The concern recently appears in journal Proceedings of the National Academy of Sciences (PNAS).
"Going forward, we want to investigate the environmental factors — particularly the nutrient conditions — that cause different adipose cell types to grow," explains biophysicist Dr. Matthias Meier. "This will enable us to develop new approaches to combating obesity and diabetes."
In contrast to embryonic stem cells, when adult stem cells divide, their offspring are only able to develop at the same site and in certain tissue types. Factors such as insulin and blood sugar levels also influence whether or not adult stem cells in adipose tissue will develop into mature adipose cell. Aberrations in this maturation process can lead to diabetes or obesity. The multitude of factors operating here make it very complicated, however, for scientists to investigate this process outside the body.
Story source: BIOSS – Centre for Biological Signalling Studies
Journal References:
Xuanye Wu, Nils Schneider, Alina Platen, Indranil Mitra, Matthias Blazek, Roland Zengerle, Roland Schüle, Matthias Meier. In situ characterization of the mTORC1 during adipogenesis of human adult stem cells on chip. Proceedings of the National Academy of Sciences, 2016; 201601207 DOI: 10.1073/pnas.1601207113
