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Scientists from Princeton University, United States recently uncover mysterious thought over bacterial antibiotic named, “Tropodithietic acid” the results shows after study of mode of action of this antibody.
The antibiotic is well addressed that helping as an anticancer agent too. This antibiotic produced by Bacteria of Roseobacter family which exists as symbiotic condition with an Algae, Bacteria provide protection from different pathogens to algae and in returns take food over algae. The study published in Proceedings of National Academy of Sciences.
The team of researcher used three types of dyes which evaluate 13 different types of diseased cells, with Tropodithietic acid profile and this matches with known drugs with anticancer activity named polyethers.
According to Researcher: Seyedsayamdost,
"We often look at natural products as black boxes," said Seyedsayamdost, "but these molecules have evolved for millennia to fulfill a certain function. By linking the unusual structural features of TDA to its mode of action, we have begun to explain why TDA looks the way it does."
Journal References
Maxwell Z. Wilson, Rurun Wang, Zemer Gitai, Mohammad R. Seyedsayamdost. Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink. Proceedings of the National Academy of Sciences, 2016; 201518034 DOI: 10.1073/pnas.1518034113
