Cardiac Muscles Cannot Regenerate in Case of Humans why
- Post By : Microbioz India
- Source: University of Erlangen-Nuremberg
- Date: 09 August, 2015
Generally cardiac muscle cells die after damaging of heart which leads to loose of normal heart function and cause severe attack and death then after.
Amphibians have nature of regenerating cardiac muscle cells after damaging of heart, and they all can cope up with these conditions. Scientists find way and mechanism why this regeneration system is not possible in human beings. This explanation is recently published in high-profile journal eLife*.
The research is led by Dr. David Zebrowski and Prof. Dr. Felix B. Engel from the Department of Nephropathology at Universitätsklinikum Erlangen's Institute of Pathology.
According to Original Research:
The ability of most cardiac muscle cells to reproduce disappears in humans and all other mammals shortly after birth. What remains unclear, however, is how this happens and whether it is possible to restore this ability and therefore to regenerate the heart.'In our study we discovered that the centrosome in cardiac muscle cells undergoes a process of disassembly which is completed shortly after birth,' Prof. Engel explains. 'This disassembly process proceeds by some proteins leaving the centrosome and relocating to the membrane of the cell nucleus in which the DNA is stored. This process causes the centrosome to break down into the two centrioles of which it is composed, and this causes the cell to lose its ability to reproduce.'
According to Dr. David Zebrowski:
'We were incredibly surprised to discover that the centrosome in the cardiac muscle cells of zebrafish and amphibians remains intact into adulthood,' says Dr. David Zebrowski, who has been studying centrosomes for five years. 'For the first time, we have discovered a significant difference between the cardiac muscle cells of mammals and those of zebrafish and amphibians that presents a possible explanation as to why the human heart cannot regenerate.'
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