Swedish Researchers Identified Few Cancerous Cells Become More Aggressive By Accumulating Fat: Research Study
- Post By : Microbioz India
- Source: University of Lund
- Date: 04 June, 2016
Researcher from University of Lund identified few cancer cell become more aggressive after accumulating fat droplets and which could not be then treated through chemotherapy or radiations.
According to research the inner structure of cancer tumor has Oxygen deficiency, low pH and lack of nutrients and these type of cell survived under these condition are called stressed cells and is more aggressive than others.
According to researcher,
"In order to survive inside the tumour, the stressed cells go into a resting phase. They then become inaccessible to radiation and chemotherapy, but can still accumulate fat droplets. The fat serves as fuel for them, when they later leave their resting phase to grow and spread," explains Mattias Belting.
That cells of a cancerous tumour experience a shift between "good and bad times" has been known for some time. From a cancer cell's point of view, "good times" is when the cancer can spread and cause a relapse.
"We know that only a very small percentage of the cancer cells that enter the blood stream are capable of forming metastases. We believe that it is the cancer cells that are similar to fat cells that are most capable of forming metastases. They can either use fat deposits for energy, to build their cell membranes, or to manufacture signal substances -- or do all of this at the same time," says doctoral student Julien Menard, who is the lead author of the research article, which the group has now published in Cancer Research.
Story source: University of Lund
J. Menard, H. C. Christianson, P. Kucharzewska, E. Bourseau-Guilmain, K. J. Svensson, E. Lindqvist, V. Indira Chandran, L. Kjellen, C. Welinder, J. Bengzon, M. C. Johansson, M. Belting. Metastasis stimulation by hypoxia and acidosis-induced extracellular lipid uptake is mediated by proteoglycan-dependent endocytosis. Cancer Research, 2016; DOI: 10.1158/0008-5472.CAN-15-2831