Quantifying Adeno Associated Virus Aggregation
Microbioz India, October, 2019 Issue
Cover Story : “Quantifying Adeno Associated Virus Aggregation"
Volume : Volume 5 Issue 10
Dear friends and readers, I hope you would have enjoyed reading our previous issue. Once again, I am delighted to bring to you the October 2019 edition of Microbioz India magazine supported by the cover story entitled “Quantifying Adeno-Associated Virus Aggregation” an informative product specification article submitted by Postnova Analytics GmbH.
Adeno-associated viruses are gaining widespread popularity as vehicles for gene therapy due to their versatility and safety. However, one of the biggest concerns for manufacturing a uniform AAV suspension is the presence of viral aggregates, which can create problems with transduction efficiency, bio distribution, and immunogenicity. Due to their large size, often over 100 nm in diameter, AAV aggregates are challenging to separate and characterize by traditional column-based chromatography techniques.
Along with cover story the issue also having a featured article titled “New way to test for drug resistant infections” based on a method to test whether an infection is resistant to common antibiotics. Scientists from the University of York modified an antibiotic from the beta-lactam family so that it can be attached to a sensor, enabling them to detect the presence of bacteria resistant to treatment.